首頁 > 試劑耗材 > Gadospin D MRI 動態增強造影劑

Gadospin D球狀結構中包含24個釓離子。Gadospin TM D是一可實現MRI對血管完整性、血管生成以及炎癥組織動態對比增強(DCE)的造影劑。

Gadospin D.pngGadospin D 1.png 

(左圖)Gadospin D的 DEC-MRI腫瘤治療監測。小鼠腫瘤抗血管研究,針對腫瘤區域內血管對造影劑的攝取分析。T1加權成像可以明顯看到治療組中腫瘤血管對造影劑的吸收明顯低于對照組,原因可以歸結于藥物對新生血管的抑制效果。


參考文獻

1. Su, M. Y.et al. (2002) Measurement of volumetric and vascular changes with dynamic contrast enhanced MRI for cancer therapy monitoring. Technol. Cancer Res. Treat. 1:479-488.

2. Verhoye, M. et al. (2002) Assessment of the neovascular permeability in glioma xenografts by dynamicT(1) MRI with Gadomer-17. Magn. Reson. Med 47:305-313.

3. Fink, C. et al. (2003) High-resolution three-dimensional MR angiography of rodent tumors: morphologic characterization of intratumoral vasculature. J. Magn. Reson. Imaging 18:59-65.

4. Hamzah, J. et al. (2008) Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 453:410-414.


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